Small molecule · CNS / Psychiatric

Citalopram

Celexa
Small moleculeSelective serotonin reuptake inhibitor (SSRI)

PubChem CID 2771 · 3D model

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Eases depression by blocking the brain's reabsorption of , and it's the parent 50/50 molecule mixture from which the more potent single-molecule drug escitalopram was later purified out.

How it works

Citalopram works by blocking the reabsorption of serotonin, a brain chemical linked to mood, so more of it stays available between nerve cells. The pill people take is actually a 50/50 mix of two mirror-image versions of the same molecule, but only one of those two versions — the 'S' form — does almost all of the actual work; the other version barely helps and may even get slightly in the way of the S-form doing its job. That S-form was later purified out on its own and sold as a different drug, escitalopram, also on this site, at a lower dose. Citalopram also carries a specific warning: taking more than 40 mg a day raises the risk of a heart-rhythm change called QT prolongation, so doses are capped there.

What it’s used for

Citalopram is approved to treat major depressive disorder in adults.

Mechanism
Selective serotonin (SSRI)
Drug class
Therapeutic area
CNS / Psychiatric

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