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199 COMPOUNDS AND COUNTING — HOVER OR TAP TO INSPECT
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Ibuprofen
Advil
COX-1 / COX-2 inhibitor
Orforglipron
Foundayo
GLP-1 receptor agonist (non-peptide, oral)
Atorvastatin
Lipitor
HMG-CoA reductase inhibitor
Metformin
Glucophage
AMPK activator, reduces hepatic glucose output
Omeprazole
Prilosec
Proton pump (H+/K+ ATPase) inhibitor
Amoxicillin
Amoxil
Beta-lactam, inhibits cell wall synthesis
Sertraline
Zoloft
Selective serotonin reuptake inhibitor (SSRI)
Losartan
Cozaar
Angiotensin II receptor (AT1) blocker
Metoprolol
Lopressor
Beta-1 adrenergic receptor antagonist
Levothyroxine
Synthroid
Thyroid hormone receptor agonist
Amlodipine
Norvasc
L-type calcium channel blocker
Gabapentin
Neurontin
Alpha-2-delta calcium channel subunit modulator
Sildenafil
Viagra
Phosphodiesterase-5 (PDE5) inhibitor
Warfarin
Coumadin
Vitamin K epoxide reductase inhibitor
Fluoxetine
Prozac
Selective serotonin reuptake inhibitor (SSRI)
Clopidogrel
Plavix
P2Y12 receptor antagonist
Azithromycin
Zithromax
Inhibits 50S ribosomal subunit
Albuterol
Ventolin / ProAir
Beta-2 adrenergic receptor agonist
Lisinopril
Zestril
ACE (angiotensin-converting enzyme) inhibitor
Simvastatin
Zocor
HMG-CoA reductase inhibitor
Tamoxifen
Nolvadex
Selective estrogen receptor modulator (SERM)
Imatinib
Gleevec
BCR-ABL tyrosine kinase inhibitor
Sitagliptin
Januvia
DPP-4 inhibitor
Rosuvastatin
Crestor
HMG-CoA reductase inhibitor
Esomeprazole
Nexium
Proton pump (H+/K+ ATPase) inhibitor
Osimertinib
Tagrisso
EGFR tyrosine kinase inhibitor (mutant-selective: exon 19 deletion, L858R, and T790M)
Diltiazem
Cardizem
Non-dihydropyridine calcium channel blocker
Hydrochlorothiazide
Microzide
Thiazide diuretic (Na+/Cl- cotransporter inhibitor)
Digoxin
Lanoxin
Na+/K+-ATPase inhibitor (positive inotrope)
Empagliflozin
Jardiance
SGLT2 inhibitor
Glipizide
Glucotrol
Sulfonylurea, stimulates pancreatic insulin release
Diazepam
Valium
GABA-A receptor positive allosteric modulator
Escitalopram
Lexapro
Selective serotonin reuptake inhibitor (SSRI)
Quetiapine
Seroquel
Atypical antipsychotic (D2 / 5-HT2A antagonist)
Levetiracetam
Keppra
Binds synaptic vesicle protein SV2A
Acetaminophen
Tylenol
Central COX inhibition (analgesic / antipyretic)
Morphine
MS Contin
Mu-opioid receptor agonist
Ciprofloxacin
Cipro
Fluoroquinolone, inhibits DNA gyrase / topoisomerase IV
Doxycycline
Vibramycin
Tetracycline, inhibits 30S ribosomal subunit
Fluconazole
Diflucan
Inhibits fungal CYP450 lanosterol 14-alpha-demethylase
Montelukast
Singulair
Leukotriene receptor (CysLT1) antagonist
Fluticasone
Flonase
Glucocorticoid receptor agonist (corticosteroid)
Ondansetron
Zofran
5-HT3 receptor antagonist
Loperamide
Imodium
Peripheral mu-opioid receptor agonist
Erlotinib
Tarceva
EGFR tyrosine kinase inhibitor
Palbociclib
Ibrance
CDK4/6 inhibitor
Apixaban
Eliquis
Factor Xa inhibitor
Aspirin
Bayer
Irreversible COX-1 inhibitor (antiplatelet)
Isotretinoin
Accutane
Retinoid (precise mechanism not fully established)
Latanoprost
Xalatan
Prostaglandin F2-alpha analog
Finasteride
Propecia
5-alpha-reductase inhibitor
Loratadine
Claritin
Second-generation H1 histamine receptor antagonist
Cetirizine
Zyrtec
Second-generation H1 histamine receptor antagonist
Diphenhydramine
Benadryl
First-generation H1 histamine receptor antagonist
Fexofenadine
Allegra
Second-generation H1 histamine receptor antagonist
Levonorgestrel
Plan B One-Step
Synthetic progestin — progesterone receptor agonist
Norethindrone
Camila
Synthetic progestin — progesterone receptor agonist
Naproxen
Aleve
COX-1 / COX-2 inhibitor
Sumatriptan
Imitrex
Selective 5-HT1B/1D receptor agonist
Rizatriptan
Maxalt
Selective 5-HT1B/1D receptor agonist
Ubrogepant
Ubrelvy
CGRP receptor antagonist
Rimegepant
Nurtec ODT
CGRP receptor antagonist
Cisplatin
Platinol
Platinum-based DNA crosslinking agent
Doxorubicin
Adriamycin
Topoisomerase II inhibitor / DNA intercalator
Paclitaxel
Taxol
Microtubule stabilizer
Fluorouracil
Adrucil
Thymidylate synthase inhibitor (antimetabolite)
Methotrexate
Trexall
Dihydrofolate reductase inhibitor (antimetabolite)
Vincristine
Oncovin
Microtubule inhibitor (vinca alkaloid)
Oseltamivir
Tamiflu
Neuraminidase inhibitor
Acyclovir
Zovirax
Viral DNA polymerase inhibitor (guanosine analog)
Sofosbuvir
Sovaldi
NS5B RNA polymerase inhibitor (nucleotide analog)
Remdesivir
Veklury
RNA-dependent RNA polymerase inhibitor (nucleotide analog)
Nirmatrelvir
Paxlovid
SARS-CoV-2 main protease (3CLpro) inhibitor
Tenofovir disoproxil
Viread
Reverse transcriptase inhibitor (nucleotide analog)
Ritonavir
Norvir
HIV protease inhibitor
Captopril
Capoten
ACE (angiotensin-converting enzyme) inhibitor
Vancomycin
Vancocin
Glycopeptide antibiotic, inhibits bacterial cell-wall (peptidoglycan) biosynthesis
Metronidazole
Flagyl
Nitroimidazole, forms DNA-damaging free radicals inside anaerobic bacteria/protozoa
Clindamycin
Cleocin
Lincosamide, inhibits bacterial protein synthesis via the 50S ribosomal subunit
Terbinafine
Lamisil
Inhibits fungal squalene epoxidase, blocking ergosterol synthesis
Amphotericin B
AmBisome
Binds fungal ergosterol, forming membrane pores that cause ion leakage
Caspofungin
Cancidas
Inhibits fungal beta-(1,3)-D-glucan synthase, disrupting cell wall synthesis
Prednisone
Deltasone
Glucocorticoid receptor agonist (corticosteroid)
Dexamethasone
Decadron
Glucocorticoid receptor agonist (corticosteroid)
Hydrocortisone
Cortef
Glucocorticoid receptor agonist (corticosteroid)
Pyridostigmine
Mestinon
Acetylcholinesterase inhibitor
Linagliptin
Tradjenta
DPP-4 inhibitor, increases active incretin hormone levels
Lithium
Lithobid
Mood stabilizer, mechanism of antimanic action not fully established
Alprazolam
Xanax
Benzodiazepine, GABA-A receptor positive allosteric modulator
Methylphenidate
Concerta
CNS stimulant, blocks dopamine and norepinephrine reuptake
Oxycodone
Roxicodone
Full opioid agonist, binds mu-opioid receptors to block pain signaling
Rivaroxaban
Xarelto
Factor Xa inhibitor, blocks clotting cascade to reduce thrombin generation
Tofacitinib
Xeljanz
JAK inhibitor, blocks cytokine signaling that drives inflammation
Lamotrigine
Lamictal
Voltage-gated sodium channel blocker, anticonvulsant
Zolpidem
Ambien
GABA-A receptor positive modulator (non-benzodiazepine hypnotic)
Tadalafil
Cialis
Phosphodiesterase-5 (PDE5) inhibitor
Isoniazid
Nydrazid
Isonicotinic acid hydrazide, inhibits mycolic acid synthesis (antimycobacterial)
Ivacaftor
Kalydeco
CFTR potentiator, increases chloride channel open probability
Epinephrine
EpiPen
Non-selective alpha/beta-adrenergic agonist, reverses vasodilation and bronchospasm
Naloxone
Narcan
Opioid receptor antagonist, competitively displaces opioids from receptors
Atropine
AtroPen
Muscarinic acetylcholine receptor antagonist, blocks acetylcholine to reverse bradycardia and cholinergic toxicity
Nitroglycerin
Nitrostat
Nitrate vasodilator, releases nitric oxide to relax vascular smooth muscle
Amiodarone
Pacerone
Class III antiarrhythmic, blocks potassium channels to prolong cardiac repolarization
Esketamine
Spravato
Non-competitive NMDA receptor antagonist
Furosemide
Lasix
Loop diuretic (Na+/K+/2Cl- cotransporter inhibitor)
Ivermectin
Stromectol
Glutamate-gated chloride channel agonist
Artesunate
Artesunate for Injection
Endoperoxide-mediated oxidative damage (antimalarial)
Colchicine
Colcrys
Tubulin-binding microtubule inhibitor
Verteporfin
Visudyne
Light-activated photosensitizer (photodynamic therapy)
Cyclosporine
Neoral
Calcineurin inhibitor (immunosuppressant)
Sirolimus
Rapamune
FKBP-12/mTOR inhibitor
Pantoprazole
Protonix
Proton pump (H+/K+ ATPase) inhibitor
Famotidine
Pepcid
Histamine H2-receptor antagonist
Sennoside A
Senokot
Stimulant laxative (prodrug → rhein anthrone)
Docusate sodium
Colace
Stool softener (anionic surfactant)
Celecoxib
Celebrex
COX-2 selective inhibitor
Valbenazine
Ingrezza
VMAT2 inhibitor (prodrug)
Citalopram
Celexa
Selective serotonin reuptake inhibitor (SSRI)
Propofol
Diprivan
GABA-A receptor positive allosteric modulator (general anesthetic)
Adalimumab
Humira
TNF-alpha inhibitor (monoclonal antibody)
Trastuzumab
Herceptin
HER2 receptor antagonist (mAb)
Insulin glargine
Lantus
Insulin receptor agonist (long-acting analog)
Rituximab
Rituxan
CD20-directed cytolytic antibody (mAb)
Etanercept
Enbrel
TNF receptor–Fc fusion protein (decoy receptor)
Bevacizumab
Avastin
VEGF-A inhibitor (mAb)
Infliximab
Remicade
TNF-alpha inhibitor (mAb)
Pembrolizumab
Keytruda
PD-1 checkpoint inhibitor (mAb)
Nivolumab
Opdivo
PD-1 checkpoint inhibitor (mAb)
Semaglutide
Ozempic / Wegovy / Rybelsus
GLP-1 receptor agonist (peptide analog)
Omalizumab
Xolair
IgE antagonist (mAb)
Denosumab
Prolia
RANKL inhibitor (mAb)
Ustekinumab
Stelara
IL-12 / IL-23 antagonist (mAb)
Secukinumab
Cosentyx
IL-17A antagonist (mAb)
Ranibizumab
Lucentis
VEGF-A inhibitor (Fab fragment)
Alemtuzumab
Lemtrada
CD52 antagonist (mAb)
Natalizumab
Tysabri
Alpha-4 integrin antagonist (mAb)
Evolocumab
Repatha
PCSK9 inhibitor (mAb)
Dupilumab
Dupixent
IL-4Rα antagonist (mAb)
Tocilizumab
Actemra
IL-6 receptor antagonist (mAb)
Vedolizumab
Entyvio
α4β7 integrin antagonist (mAb)
Ipilimumab
Yervoy
CTLA-4 checkpoint inhibitor (mAb)
Golimumab
Simponi
TNF-alpha inhibitor (mAb)
Certolizumab pegol
Cimzia
TNF-alpha inhibitor (PEGylated Fab fragment)
Daratumumab
Darzalex
CD38 antagonist (mAb)
Cetuximab
Erbitux
EGFR antagonist (mAb)
Panitumumab
Vectibix
EGFR antagonist (mAb)
Trastuzumab emtansine
Kadcyla
HER2-targeted antibody-drug conjugate
Brentuximab vedotin
Adcetris
CD30-targeted antibody-drug conjugate
Atezolizumab
Tecentriq
PD-L1 checkpoint inhibitor (mAb)
Risankizumab
Skyrizi
IL-23 antagonist (mAb)
Guselkumab
Tremfya
IL-23 antagonist (mAb)
Abatacept
Orencia
CTLA-4-Ig fusion protein (T-cell costimulation blocker)
Belimumab
Benlysta
BLyS/BAFF antagonist (mAb)
Sarilumab
Kevzara
IL-6 receptor antagonist (mAb)
Tirzepatide
Mounjaro / Zepbound
GLP-1 / GIP dual receptor agonist (peptide analog)
Liraglutide
Victoza
GLP-1 receptor agonist (peptide analog)
Teriparatide
Forteo
Parathyroid hormone (PTH) receptor agonist
Eculizumab
Soliris
Complement C5 inhibitor (mAb)
Romiplostim
Nplate
Thrombopoietin receptor agonist (Fc-peptide fusion)
Emicizumab
Hemlibra
Bispecific antibody mimicking Factor VIIIa
Mepolizumab
Nucala
IL-5 antagonist (mAb)
Benralizumab
Fasenra
IL-5 receptor alpha antagonist (cytolytic mAb)
Erenumab
Aimovig
CGRP receptor antagonist (mAb)
Ocrelizumab
Ocrevus
CD20 antagonist (mAb)
Aflibercept
Eylea
VEGF-A / PlGF trap (fusion protein)
Ixekizumab
Taltz
IL-17A antagonist (mAb)
Brodalumab
Siliq
IL-17 receptor A antagonist (mAb)
Palivizumab
Synagis
RSV F protein antagonist (mAb)
Basiliximab
Simulect
IL-2 receptor (CD25) antagonist (mAb)
Tisagenlecleucel
Kymriah
Autologous anti-CD19 CAR-T cell therapy
Axicabtagene ciloleucel
Yescarta
Autologous anti-CD19 CAR-T cell therapy
Exagamglogene autotemcel
Casgevy
CRISPR-Cas9 gene-edited autologous hematopoietic stem cells (BCL11A enhancer disruption)
Tozinameran
Comirnaty
Lipid nanoparticle-delivered mRNA encoding the SARS-CoV-2 spike protein
Elasomeran
Spikevax
Lipid nanoparticle-delivered mRNA encoding the SARS-CoV-2 spike protein
Hepatitis B vaccine
Engerix-B
Recombinant hepatitis B surface antigen (HBsAg)
HPV vaccine
Gardasil 9
Recombinant HPV L1 capsid protein virus-like particles
Zoster vaccine
Shingrix
Recombinant varicella-zoster virus glycoprotein E
Efgartigimod
Vyvgart
Neonatal Fc receptor (FcRn) antagonist (antibody Fc fragment)
Insulin lispro
Humalog
Insulin receptor agonist (rapid-acting analog)
Lecanemab
Leqembi
Amyloid-beta protofibril-directed antibody (mAb)
Nirsevimab
Beyfortus
RSV prefusion F protein antagonist (mAb)
Filgrastim
Neupogen
G-CSF receptor agonist
Fam-trastuzumab deruxtecan
Enhertu
HER2-targeted antibody-drug conjugate
Sacituzumab govitecan
Trodelvy
Trop-2-targeted antibody-drug conjugate
OnabotulinumtoxinA
Botox
Acetylcholine release inhibitor (SNAP-25-cleaving neurotoxin)
Teplizumab
Tzield
CD3-directed T-cell modulator (monoclonal antibody)
Blinatumomab
Blincyto
Bispecific CD19/CD3 T-cell engager (BiTE)
Ciltacabtagene autoleucel
Carvykti
Autologous anti-BCMA CAR-T cell therapy
Andexanet alfa
Andexxa
Recombinant factor Xa decoy protein (reverses apixaban/rivaroxaban anticoagulation)
Linagliptin and metformin hydrochloride
Jentadueto
DPP-4 inhibitor + biguanide (fixed-dose combination)
Lisinopril and hydrochlorothiazide
Zestoretic
ACE inhibitor + thiazide diuretic (fixed-dose combination)
Losartan and hydrochlorothiazide
Hyzaar
Angiotensin II receptor blocker + thiazide diuretic (fixed-dose combination)
Metoprolol tartrate and hydrochlorothiazide
Lopressor HCT
Beta-1 receptor antagonist + thiazide diuretic (fixed-dose combination)
Amlodipine and atorvastatin
Caduet
Calcium channel blocker + HMG-CoA reductase inhibitor (fixed-dose combination)
Sitagliptin and metformin hydrochloride
Janumet
DPP-4 inhibitor + biguanide (fixed-dose combination)
Empagliflozin and metformin hydrochloride
Synjardy
SGLT2 inhibitor + biguanide (fixed-dose combination)
Glipizide and metformin hydrochloride
Metaglip
Sulfonylurea + biguanide (fixed-dose combination)
Naproxen and esomeprazole magnesium
Vimovo
NSAID + proton pump inhibitor (fixed-dose combination)
Oxycodone and acetaminophen
Percocet
Full opioid agonist + central COX inhibition (fixed-dose combination)
Ibuprofen
(Advil)
MOA:
COX-1 / COX-2
inhibitor
Area: Analgesic / Anti-inflammatory
Class:
Small molecule
Source:
PubChem CID 3672 ↗
·
FDA label (DailyMed) ↗
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