Ranibizumab
LucentisRCSB PDB 1CZ8 · 3D model
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A lab-made antibody fragment that latches onto a protein driving abnormal blood vessel growth and leakage in the eye, helping protect vision.
How it works
Inside the eye, a protein called VEGF-A can trigger the growth of fragile, leaky blood vessels that damage the retina and blur vision. Ranibizumab is a small piece of an antibody that grabs onto VEGF-A and stops it from working. With VEGF-A blocked, abnormal vessel growth and fluid leakage slow down, which helps preserve and sometimes improve sight.
What it’s used for
Used to treat several eye conditions that threaten vision through abnormal blood vessel growth or fluid buildup in the retina, including wet age-related macular degeneration and diabetes-related eye damage.
- Mechanism
- VEGF-A inhibitor (Fab fragment)
- Drug class
- Fab fragment
- Therapeutic area
- Ophthalmology